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多é‡è€è¯ç»†èŒï¼Œç‰¹åˆ«æ˜¯â€?/span>超级细èŒâ€?/span>的出现åŠè”“å»¶å·²æˆä¸ºå¨èƒäººç±»å¥åº·çš„å…¨çƒæ€§é—®é¢˜ã€‚é˜æ˜Žæ–°çš„è€è¯æœºåˆ¶å’Œå¼€å‘å…‹æœè€è¯æ€§çš„æ–°ä¸€ä»£æŠ—ç”Ÿç´ æ˜¯å½“å‰å¦æœ¯ç•Œå’Œåˆ¶è¯å·¥ä¸šç•Œå…±åŒçš„迫切需æ±?/span>ã€?/span>铜绿å‡å•胞èŒï¼?/span>Pseudomonas aeruginosa)是医院内常è§çš„æ„ŸæŸ“病原èŒï¼Œåœ¨å…疫功能低下的病人ä¸å¯å¯¼è‡´é«˜å‘病率和æ»äº¡çŽ‡ï¼Œä¸–ç•Œå«ç”Ÿç»„织早已将其列为â€?/span>critical priority pathogensâ€ã€‚铜绿å‡å•èƒžèŒæ˜¯ä¸€ç§é©å…°æ°é˜´æ€§èŒï¼Œå…¶å¤–è†œé€šé€æ€§å¾ˆä½Žï¼Œèƒ½å¤Ÿæœ‰æ•ˆé˜»ç¢è¯ç‰©åˆ†å进入到细胞内,对许多临床é‡è¦çš„æŠ—ç”Ÿç´ ï¼ˆå¦‚æ°¨è‹„è¥¿æž—ã€é˜¿èŽ«è¥¿æž—å’Œä¸‡å¤éœ‰ç´ ç‰ï¼‰å…·æœ‰å¤©ç„¶è€å—æ€§ï¼Œå› æ¤æ˜¯ä¸€ç±»å副其实的â€?/span>超级细èŒâ€?/span>ã€?/span>
近日,雷晓光课题组在ã€?/span>Chemical Science》期刊上å‘表了题ä¸?/span>“De novo synthesis, structural assignment and biological evaluation of pseudopaline, a metallophore produced by Pseudomonas aeruginosaâ€?/span>çš„ç ”ç©¶è®ºæ–‡ï¼Œé¦–æ¬¡é€šè¿‡åŒ–å¦å…?/span>åˆæˆä»¥åŠå¤©ç„¶äº§ç‰©åˆ†ç¦»èŽ·å¾—äº†ä¸€ç±»å¯¹äºŽä¿ƒè¿?/span>铜绿å‡å•胞èŒç”Ÿé•¿å’Œè€è¯è‡³å…³é‡è¦çš„天然产物分å?/span>pseudopaline,并且确定了pseudopaline相对和ç»å¯¹ç«‹ä½“构型。在æ¤åŸºç¡€ä¹‹ä¸Šï¼Œé›·æ™“å…‰è¯¾é¢˜ç»„åˆæ¥æŽ¢ç´¢äº†pseudopalineçš„ç”Ÿç‰©æ´»æ€§ï¼Œè¯æ˜Žè¯¥åˆ†å是一类广谱的金属离å螯åˆå‰‚,å¯ä»¥ä¿ƒè¿›é“œç»¿å‡å•胞èŒå¯¹äºŒä»·é‡‘属离å的转è¿ã€å¸æ”¶ï¼Œä»Žè€Œä¿ƒè¿›è¯¥ç»†èŒç”Ÿé•¿å’Œäº§ç”Ÿè€è¯æ€§ã€?/span>最åŽï¼Œé›·æ™“å…‰è¯¾é¢˜ç»„è¿˜åˆæˆäº†pseudopaline-è§å…‰ç´ çš„å¶è”ä½“ï¼Œè¯æ˜Žäº†è¯¥å¶è”体å¯ä»¥è¢«æœ‰æ•ˆåœ°è½¬è¿è¿›å…¥é“œç»¿å‡å•胞èŒï¼Œä»Žè€?/span>验è¯äº†åˆ©ç”¨è¯¥å¤©ç„¶äº§ç‰©å¼€å‘æ–°ä¸€ä»£æŠ—ç”Ÿç´ ã€ä¾‹å¦?/span>新型“特洛伊木马â€ç±»åž‹çš„pseudopaline-æŠ—ç”Ÿç´ å¶è?/span>体,帮助克æœè€è¯æœºåˆ¶çš„å¯è¡Œæ€§ã€?/span>
雷晓光课题组的åšå£«ç”Ÿå¼ å¥å’Œåšå£«åŽèµµå¤©æ¹–åšå£«ã€æ¨è£æ–‡åšå£«ä¸ºè¯¥è®ºæ–‡çš„å…±åŒç¬¬ä¸€ä½œè€…,雷晓光教授为通讯作者,瑞士罗æ°åˆ¶è¯å…¬å¸åˆ›æ–°è¯ç‰©ç ”å‘主管沈å®åšå£«ä¸ºè¯¥ç ”究工作æä¾›äº†å¸®åŠ©ã€‚è¯¥å·¥ä½œå¾—åˆ°å›½å®¶è‡ªç„¶ç§‘å¦åŸºé‡‘(æ°å‡ºé’年基金ã€é‡ç‚¹é¡¹ç›®å’Œåˆ›æ–°ç¾¤ä½“项目)ã€ç§‘技部é‡ç‚¹ç ”å‘计划ã€?/span>973项目ã€åŒ—å¤?/span>-清åŽç”Ÿå‘½è”åˆä¸å¿ƒã€ä»¥åŠç‘žå£«ç½—æ°åˆ¶è¯å…¬å¸æ—©æœŸåˆ›æ–°è¯ç‰©ç ”å‘项目的资助。æ¨è£æ–‡åšå£«è¿˜å¾—到了北大-清åŽç”Ÿå‘½è”åˆä¸å¿ƒä¼˜ç§€åšå£«åŽè®¡åˆ’的资助。目å‰é›·æ™“光课题组æ£åœ¨ä¸Žç‘žå£«ç½—æ°åˆ¶è¯å·¥ä½œåˆä½œï¼Œç§¯æžæŽ¨è¿›åŽæœŸæ–°ä¸€ä»£æŠ—ç”Ÿç´ è¯ç‰©çš„å¼€å‘ã€?/span>
原文链接: //pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC01405E