ï»? 鍒樺織鍗氳棰樼粍鎶ラ亾鈥滀笌閫昏緫闂ㄢ€滆皟鎺х殑鍙岄噸鎺у埗鍓垏鍖栧 --鐢熺墿鏈夋満涓庡垎瀛愬伐绋嬫暀鑲查儴閲嶇偣瀹為獙瀹?

伊人直播

您所在的ä½ç½®ï¼šåˆ˜å¿—åšè¯¾é¢˜ç»„报é““与逻辑门“调控的åŒé‡æŽ§åˆ¶å‰ªåˆ‡åŒ–å­¦ > 实验室新é—?/a> > 首页

实验室新�/h4>

刘志åšè¯¾é¢˜ç»„报é““与逻辑门“调控的åŒé‡æŽ§åˆ¶å‰ªåˆ‡åŒ–å­¦

作者:     æ¥æºï¼?nbsp;    å‘布日期:2022-06-08

近日,北京大学化学与分å­å·¥ç¨‹å­¦é™¢åº”用化学系刘志åšè¯¾é¢˜ç»„在ACS Central Science上å‘表了题为â€?/span>A Molecular Logic Gate for Developing “ANDâ€?Logic Probes and the Application in Hepatopathy Differentiationâ€?/span>的研究论文(DOI: 10.1021/acscentsci.2c00387)ã€?/span>该研究报é“了一类新型分å­â€œä¸Žé€»è¾‘é—?/span>â€åˆ†å­å¼€å…?/span>,能够调控功能分å­çš„åŒé‡å¯æŽ§é‡Šæ”¾ã€?/span>得益于此,作è€?/span>构建äº?/span>æˆåƒç‰¹å¼‚性更高的“与â€é—¨æŽ¢é’ˆï¼?/span>å¹?/span>æˆåŠŸåº”ç”¨äº?/span>ä¸åŒå°é¼ æ¨¡åž‹å’?/span>è‚病患者血æ¸?/span>æ ?/span>本的精准鉴别ã€?/span>

å›?/span>1. â€œä¸Žé€»è¾‘é—?/span>â€åˆ†å­å¼€å…?/span>åº?/span>用于è‚病精准诊断

疾病çš?/span>精准诊断å’?/span>治疗常常ä¾èµ–äº?/span>功能分å­çš?/span>é¶å‘递é€?/span>å’?/span>å¯æŽ§é‡Šæ”¾ã€?/span>但是ï¼?/span>ç–¾ç—…é¶æ ‡åœ¨ç”Ÿç‰?/span>体内䏿˜¯ç‹¬ä¸€æ— äºŒçš„,å•é‡å“应çš?/span>å¯æŽ§é‡Šæ”¾ç­–ç•¥éš¾ä»¥ç²¾å‡†è¯†åˆ«ç–¾ç—…éƒ¨ä½ã€?/span>å?/span>æ”¾å°„æ€§å½±åƒæŽ¢é’?/span>指导çš?/span>åŒé¶å‘ç­–ç•?/span>å¯å‘ï¼?/span>Nature,2020, 579,421-426),刘志åšå›¢é˜?/span>进一步å‘展了“与â€é€»è¾‘调控的åŒé‡å¯æŽ§é‡Šæ”¾ç­–ç•?/span>ã€?/span>

å›?/span>2. é€šç”¨åž‹åˆ†å­â€œä¸Žé€»è¾‘é—?/span>â€?/span>的化学结构åŠå·¥ä½œåŽŸç†ã€?/span>

首先,作者æˆåŠŸç­›é€‰å‡ºBicineå’?/span>Dien为骨架的两类分å­â€œä¸Žâ€?/span>逻辑é—?/span>ï¼?/span>å‘生åŒå“应åŽï¼Œå…¶èƒ½å¤Ÿå‘生快é€?/span>çš?/span>分å­å†…环化å应,并释放完整的功能分å­ï¼Œé‡Šæ”¾é€ŸçŽ‡æœ€é«˜å¯è¾?/span>å•å“åº?/span>情况çš?/span>100å€ã€?/span>åŒæ—¶ï¼?/span>作者拓展了该体系的普适性,æˆåŠŸå?/span>è”多ç§è§¦å‘å“åº?/span>基团和功能分å­ã€?/span>éšåŽï¼Œä½œè€…è®¾è®¡å¹¶åˆæˆäº†å•胺氧化酶ï¼?/span>MAO)和亮氨酸氨基肽酶(LAP)åŒé‡å“应的“与â€é—¨æŽ¢é’ˆï¼Œå…¶åœ¨ç»†èƒžæˆåƒä¸­æ¯”å•å“应探针具有更低背景信å·ã€?/span>进一步地,该探针能够é™ä½Žè¡€æ¸…检测中的å‡é˜³æ€§ä¿¡å·ï¼ŒæˆåŠŸåº”ç”¨äº?/span>ä¸åŒå°é¼ æ¨¡åž‹å’?/span>è‚病患者血æ¸?/span>æ ?/span>本的精准鉴别ã€?/span>综上ï¼?/span>该工ä½?/span>å¼€å‘äº†æ–°åž‹çš„å¯æŽ§é‡Šæ”¾ç­–ç•¥ï¼Œæœ‰æœ›å¯¹ç–¾ç—…çš„ç²¾å‡†è¯Šæ–­å’Œæ²»ç–—å¸¦æ¥å…³é”®æ€§çªç ´ã€?/span>

北京大学化学与分å­å·¥ç¨‹å­¦é™?/span>ã€?/span>北大â€?/span>清åŽç”Ÿå‘½ç§‘å­¦è”åˆä¸­å¿ƒçš„刘志åšç ”究员为è¯?/span>文通讯作者,åšå£«ç ”究生陈梦çªä¸ºè¯¥æ–‡çš„第一作è€?/span>ã€?/span>刘志åšè¯¾é¢˜ç»„王春洪åŒå­¦ã€ä¸æ³?/span>è½?/span>åšå£«ã€åŒ—京大学第三医院王皓教æŽ?/span>å’?/span>北京å和医院王裕教授为本工作åšå‡ºäº†é‡è¦è´¡çŒ®ã€?/span>感谢中国科学院化学研究所马会民教æŽ?/span>ã€?/span>刘志åšè¯¾é¢˜ç»„王轩宇åŒå­?/span>ã€?/span>北京大学第三医院æ¢äº¬æ´¥åšå£?/span>对该工作的支æŒ?/span>ã€?/span>该工作得到了国家自然科学基金委ã€ç§‘技部ã€åŒ—京市é‡ç‚¹ç ”å‘ä¸“é¢˜ã€æŽé?/span>-èµµå®ç”Ÿå‘½ç§‘å­¦é’年研究基金ã€?/span>昌平国家实验å®?/span>ã€?/span>北京分å­ç§‘学国家研究中心以åŠåŒ—大â€?/span>清åŽç”Ÿå‘½ç§‘å­¦è”åˆä¸­å¿ƒçš„资助ã€?/span>

原文链接�/span>//doi.org/10.1021/acscentsci.2c00387

@ ç‰ˆæƒæ‰€æœ?è¿è€…å¿…ç©?/br>è”系方å¼:北京市海淀区æˆåºœè·¯202å?北京大学化学与分å­å·¥ç¨‹å­¦é™¢ï¼Œé‚®ç¼–:100871
电è¯ï¼?10ï¼?275ï¼?248;传真:010ï¼?275ï¼?708