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首先,作者æˆåŠŸç›é€‰å‡ºBicineå’?/span>Dien为骨架的两类分å“与â€?/span>逻辑é—?/span>ï¼?/span>å‘生åŒå“应åŽï¼Œå…¶èƒ½å¤Ÿå‘生快é€?/span>çš?/span>分å内环化å应,并释放完整的功能分å,释放速率最高å¯è¾?/span>å•å“åº?/span>情况çš?/span>100å€ã€?/span>åŒæ—¶ï¼?/span>作者拓展了该体系的普适性,æˆåŠŸå?/span>è”多ç§è§¦å‘å“åº?/span>基团和功能分åã€?/span>éšåŽï¼Œä½œè€…è®¾è®¡å¹¶åˆæˆäº†å•胺氧化酶ï¼?/span>MAO)和亮氨酸氨基肽酶(LAP)åŒé‡å“应的“与â€é—¨æŽ¢é’ˆï¼Œå…¶åœ¨ç»†èƒžæˆåƒä¸æ¯”å•å“应探针具有更低背景信å·ã€?/span>进一æ¥åœ°ï¼Œè¯¥æŽ¢é’ˆèƒ½å¤Ÿé™ä½Žè¡€æ¸…检测ä¸çš„å‡é˜³æ€§ä¿¡å·ï¼ŒæˆåŠŸåº”ç”¨äº?/span>ä¸åŒå°é¼ 模型å’?/span>è‚病患者血æ¸?/span>æ ?/span>本的精准鉴别ã€?/span>综上ï¼?/span>该工ä½?/span>å¼€å‘äº†æ–°åž‹çš„å¯æŽ§é‡Šæ”¾ç–略,有望对疾病的精准诊æ–和治疗带æ¥å…³é”®æ€§çªç ´ã€?/span>
北京大å¦åŒ–å¦ä¸Žåˆ†å工程å¦é™?/span>ã€?/span>北大â€?/span>清åŽç”Ÿå‘½ç§‘å¦è”åˆä¸å¿ƒçš„刘志åšç ”究员为è¯?/span>文通讯作者,åšå£«ç ”究生陈梦çªä¸ºè¯¥æ–‡çš„第一作è€?/span>ã€?/span>刘志åšè¯¾é¢˜ç»„王春洪åŒå¦ã€ä¸æ³?/span>è½?/span>åšå£«ã€åŒ—京大å¦ç¬¬ä¸‰åŒ»é™¢çŽ‹çš“æ•™æŽ?/span>å’?/span>北京å和医院王裕教授为本工作åšå‡ºäº†é‡è¦è´¡çŒ®ã€?/span>感谢ä¸å›½ç§‘å¦é™¢åŒ–å¦ç ”究所马会民教æŽ?/span>ã€?/span>刘志åšè¯¾é¢˜ç»„王轩宇åŒå?/span>ã€?/span>北京大å¦ç¬¬ä¸‰åŒ»é™¢æ¢äº¬æ´¥åšå£?/span>对该工作的支æŒ?/span>ã€?/span>该工作得到了国家自然科å¦åŸºé‡‘å§”ã€ç§‘技部ã€åŒ—京市é‡ç‚¹ç ”å‘ä¸“é¢˜ã€æŽé?/span>-èµµå®ç”Ÿå‘½ç§‘å¦é’å¹´ç ”ç©¶åŸºé‡‘ã€?/span>昌平国家实验å®?/span>ã€?/span>北京分åç§‘å¦å›½å®¶ç ”ç©¶ä¸å¿ƒä»¥åŠåŒ—大â€?/span>清åŽç”Ÿå‘½ç§‘å¦è”åˆä¸å¿ƒçš„资助ã€?/span>
原文链接�/span>//doi.org/10.1021/acscentsci.2c00387