伊人直播

The cyclohexane moiety is a ubiquitous structural motif which is widely found in drugs, agrochemicals, and natural products. Because the direct functionalization of cyclohexane is much more difficult than that on arenes, the reduction of arenes has become a crucial method for accessing substituted cyclohexanes. However, the presence of aromatic stabilization in arenes typically makes such transformations difficult, necessitating high pressure of hydrogen gas and high reaction temperatures. 

Now Prof. Zhi-Xiang Yu and Hanxiao Li from the College of Chemistry and Molecular Engineering at Peking University found that, by combining two commercially available catalysts, the hydrogenation of arenes can be achieved under ambient conditions, employing only 1 atm hydrogen gas at room temperature (Organic Letters 2024, 26, 3458-3462, //pubs.acs.org/doi/10.1021/acs.orglett.4c01029, and Chinese Patent: CN2024103221423). The catalyst combination may consist of Rh and Pd/C or Rh and Pt with low catalyst loading. Importantly, these catalysts can be reused several times for gram-scale reduction of arenes. The research was supported by the National Natural Science Foundation of China and the Beijing National Laboratory for Molecular Sciences.